For demonstration of direct HCN detection in the gas phase, a gold-coated silicon nanopillar substrate was exposed to 5 ppm HCN in N 2. The triple bond between C and N in cyanide, with its characteristic band at ∼2133 cm −1, is an excellent case for the SERS-based detection due to the infrequent occurrence of triple bonds in nature. For early PA detection in CF children not yet chronically lung infected a non-invasive Surface-Enhanced Raman Spectroscopy (SERS)-based breath nanosensor is being developed. Hydrogen cyanide (HCN) at ppb level has been reported to be a PA biomarker. Due to its ready adaptation to the dehydrated mucosa of CF airways, PA infections tend to become chronic, eventually killing the patient. Lung infections with Pseudomonas aeruginosa (PA) is the most common cause of morbidity and mortality in cystic fibrosis (CF) patients.
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